Opportunity Information: Apply for W81XWH 22 LCRP CA

The DoD Lung Cancer Research Program (LCRP) Concept Award (FY22), administered by the Department of Defense through the U.S. Army Medical Research Acquisition Activity (USAMRAA), is designed to fund bold, early-stage lung cancer ideas that are not simply the next step of existing work. The program is looking for innovative, high-risk projects with the potential for high reward, meaning proposals should aim to introduce genuinely new insights, paradigms, technologies, or applications that could shift how lung cancer is understood, studied, detected, prevented, or treated. A key expectation is that the work will lay the groundwork for future research directions rather than deliver a fully mature, near-clinical product. The funding mechanism is offered as a grant or cooperative agreement under CFDA 12.420, and eligibility is broadly open (unrestricted) unless otherwise limited by additional eligibility language in the full announcement.

Applications must present a clear, testable hypothesis supported by strong scientific reasoning and a sound study design. While preliminary data can be included, it is not required, and reviewers are instructed not to penalize applicants for lacking it. In fact, the program signals that including extensive preliminary results may indicate the project is too advanced for a “concept” mechanism and might fit better under a different LCRP funding opportunity. The main deliverable for this award is robust preliminary data that can serve as a foundation for later-stage proposals, follow-on studies, or larger translational efforts. One explicit boundary is that proposals focused only on mesothelioma are not allowed; projects need to be centered on lung cancer rather than being exclusively mesothelioma research.

A notable feature of this opportunity is the option to apply under a “Care Delivery and Health Disparity” track. This option encourages projects that address comprehensive lung cancer care and/or lung cancer-related health disparities within the program’s stated Areas of Emphasis. Importantly, submissions to this option are reviewed separately from applications in the more traditional “Cancer Research Continuum” track, which can matter for how proposals are compared and prioritized. In practical terms, applicants focused on access to care, quality of care, implementation, real-world outcomes, or inequities in screening, diagnosis, treatment, and survivorship may find this dedicated pathway better aligned with their aims and evaluation context.

Military health relevance is also a central programmatic consideration. The LCRP emphasizes funding research that connects to the needs of Service Members, Veterans, and their families, and that relevance is weighed during programmatic review when deciding how well an application fits the mission of the Defense Health Program (DHP) and the LCRP. Applicants are encouraged to demonstrate this relevance in concrete ways, such as using military or Veteran populations, leveraging military/VA biospecimens or databases, partnering with DoD or VA investigators, or explicitly addressing lung cancer risks and realities that may be distinctive for military communities. The opportunity specifically points to environmental exposures beyond tobacco as an example area of potential military-specific relevance, reflecting concern for occupational or deployment-related exposures that could influence lung cancer risk or outcomes.

From an administrative snapshot, the opportunity is titled “DoD Lung Cancer, Concept Award” with funding opportunity number W81XWH-22-LCRP-CA. It was posted March 16, 2022, with an original closing date of May 17, 2022, and the program anticipated making around 12 awards. The listing shows the award ceiling as “0,” which typically signals that applicants must rely on the full funding announcement for the actual budget limits and allowable costs rather than the summary field. Overall, this award is best understood as seed funding for daring lung cancer concepts backed by rigorous logic and a strong plan, with added emphasis on projects that either improve care delivery and reduce disparities or clearly connect to the health needs of military and Veteran populations.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lung Cancer, Concept Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 16, 2022.
  • Applicants must submit their applications by May 17, 2022 Revised. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 12 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 22 LCRP CA

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FAQs: DoD Lung Cancer Research Program (LCRP) Concept Award (FY22)

1) What is the purpose of the LCRP Concept Award (FY22)?

The LCRP Concept Award (FY22) is intended to support bold, early-stage lung cancer research ideas that are not simply the next logical step of an existing line of work. The emphasis is on innovative, high-risk/high-reward concepts that could introduce new insights, paradigms, technologies, or applications that shift how lung cancer is understood, studied, detected, prevented, or treated.

2) Who administers this grant opportunity?

This opportunity is offered by the Department of Defense (DoD) and administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the DoD Lung Cancer Research Program (LCRP).

3) What is the official funding opportunity title and number?

The title is "DoD Lung Cancer, Concept Award" and the funding opportunity number is W81XWH-22-LCRP-CA.

4) What type of funding mechanism is used?

The Concept Award is offered as a grant or cooperative agreement.

5) What is the CFDA number for this opportunity?

The CFDA number listed for this opportunity is 12.420.

6) Is eligibility restricted?

Eligibility is described as broadly open (unrestricted) unless additional eligibility language in the full announcement places limits. Based on the information provided here, no specific restrictions are listed beyond what is stated elsewhere in the full announcement.

7) What kinds of research projects are a good fit for a "Concept Award"?

Projects that propose genuinely new lung cancer concepts with strong scientific reasoning and a sound study design. The award is positioned as seed funding for daring ideas that can generate robust preliminary data and open future research directions, rather than producing a fully mature or near-clinical product.

8) What does "high-risk/high-reward" mean in this context?

It means the program is willing to consider ideas that are early, unconventional, or uncertain (high-risk) as long as they are well-reasoned and rigorously planned, and have the potential to create meaningful advances (high-reward) in how lung cancer is approached.

9) Do applicants need preliminary data?

No. Preliminary data may be included but is not required. Reviewers are instructed not to penalize applications that do not include preliminary data.

10) Can including a lot of preliminary data hurt the fit for this award?

It can be a signal of poor fit. The program notes that extensive preliminary results may indicate the proposed work is too advanced for a "concept" mechanism and might be better suited to a different LCRP funding opportunity.

11) What are applications expected to include scientifically?

Applications must present a clear, testable hypothesis supported by strong scientific reasoning and a sound study design.

12) What is the main deliverable or expected outcome of this award?

The main deliverable is robust preliminary data that can serve as the foundation for later-stage proposals, follow-on studies, or larger translational efforts.

13) Is this award intended to produce a near-clinical product?

No. A key expectation is that the work lays groundwork for future directions rather than delivering a fully mature, near-clinical product.

14) Are projects focused only on mesothelioma allowed?

No. Proposals focused exclusively on mesothelioma are not allowed. Projects must be centered on lung cancer rather than being only mesothelioma research.

15) What tracks or submission options are available?

This opportunity includes an option to apply under a "Care Delivery and Health Disparity" track, in addition to a more traditional "Cancer Research Continuum" track.

16) What is the "Care Delivery and Health Disparity" track intended for?

It is intended for projects that address comprehensive lung cancer care and/or lung cancer-related health disparities within the program's stated Areas of Emphasis. Examples of themes mentioned include access to care, quality of care, implementation, real-world outcomes, and inequities in screening, diagnosis, treatment, and survivorship.

17) Are applications reviewed differently depending on the track chosen?

Yes. Submissions to the "Care Delivery and Health Disparity" option are reviewed separately from applications in the "Cancer Research Continuum" track, which can affect how proposals are compared and prioritized.

18) How important is military health relevance?

Military health relevance is a central programmatic consideration. The LCRP emphasizes funding research that connects to the needs of Service Members, Veterans, and their families, and that relevance is weighed during programmatic review when assessing fit with the Defense Health Program (DHP) mission and LCRP priorities.

19) How can an applicant demonstrate military or Veteran relevance?

Examples given include using military or Veteran populations, leveraging military/VA biospecimens or databases, partnering with DoD or VA investigators, or explicitly addressing lung cancer risks and realities that may be distinctive for military communities.

20) Are non-tobacco exposures relevant to this program?

Yes. The opportunity specifically highlights environmental exposures beyond tobacco as an example area that may be relevant for military-specific needs, reflecting concern for occupational or deployment-related exposures that could influence lung cancer risk or outcomes.

21) What is the posted timeline for this funding opportunity?

The opportunity was posted on March 16, 2022, with an original closing date of May 17, 2022.

22) How many awards were anticipated?

The program anticipated making around 12 awards.

23) What is the award ceiling (maximum budget) for applicants?

The listing shows the award ceiling as "0," which typically indicates that the actual budget limits and allowable costs must be confirmed in the full funding announcement rather than relying on the summary field.

24) What should applicants do if they need the exact budget limits and allowable costs?

They should rely on the full funding announcement for the official budget limits, cost allowability, and any detailed administrative requirements, since the summary ceiling field is not informative here.

25) What is the overall "best use" of this award for a research team?

This award is best used as seed funding to test a daring lung cancer concept with rigorous logic and a strong plan, generate solid preliminary data, and position the team for follow-on proposals or larger translational efforts, while aligning (where possible) with care delivery/disparities priorities and/or military and Veteran health relevance.

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