Opportunity Information: Apply for HT942525TERPCTPA
The DoD Toxic Exposures Clinical Trial Partnership Award (CTPA) is a Fiscal Year 2025 funding opportunity under the Toxic Exposures Research Program (TERP) intended to speed the launch and execution of clinical trials that could materially improve how health problems linked to military-related toxic exposures are prevented, treated, or managed. The program is focused on moving interventions into real-world testing rather than supporting early-stage basic research alone, with the expectation that supported trials will be positioned to deliver clinically meaningful evidence for service members, veterans, and other affected populations. In practical terms, the award is designed to help research teams quickly stand up the partnerships, infrastructure, and coordinated study plans needed to run a credible clinical trial with clear relevance to conditions or symptoms that arise from, or are worsened by, toxic exposure histories connected to military service.
A central feature of this opportunity is flexibility in the type and scale of clinical trial work that can be proposed. Projects may be smaller, proof-of-concept efforts such as pilot studies, first-in-human testing, or phase 0 trials that mainly establish feasibility, refine protocols, and generate the data needed to justify and design larger trials. At the other end of the spectrum, applicants may propose large-scale trials, including pragmatic clinical trials designed to evaluate effectiveness in routine clinical settings and relevant patient populations. This range signals that the program is open both to exploratory clinical testing that de-risks a promising approach and to more definitive trials aimed at determining efficacy or effectiveness at scale, as long as the study addresses health outcomes associated with military-related toxic exposures.
The award emphasizes collaboration as a requirement rather than an optional strength. Applications must be built around a partnership in which an Initiating Principal Investigator leads the effort while working with at least one, and no more than two, collaborating Principal Investigators. The intent is to ensure that the proposed clinical trial is driven by a genuinely integrated team with complementary expertise, capacity, and access to the needed patient populations or clinical environments. The expectation is that these investigators are not simply listed as co-investigators, but are meaningfully engaged in delivering one overarching, unified study, with roles that support rapid implementation and successful trial execution.
Administratively, this is a discretionary grant opportunity managed by the Department of the Army through USAMRAA, and it falls under the Science and Technology/Research and Development category (CFDA 12.420). Eligibility is listed as unrestricted, which generally means a wide range of applicant organizations may apply, subject to standard federal grant rules and the specific requirements in the full announcement. The funding opportunity number is HT942525TERPCTPA, and the application closing date is October 16, 2025. The posting indicates an expectation of a single award, and while the award ceiling is not specified in the provided source text, applicants would typically need to consult the full notice for budget limits, period of performance, cost allowability, and any other constraints that shape the scope of the proposed trial.Apply for HT942525TERPCTPA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Toxic Exposures Clinical Trial Partnership Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2025-06-05.
- Applicants must submit their applications by 2025-10-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted.
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FAQs: DoD Toxic Exposures Clinical Trial Partnership Award (CTPA) - FY 2025 (TERP)
What is the DoD Toxic Exposures Clinical Trial Partnership Award (CTPA)?
The CTPA is a Fiscal Year 2025 funding opportunity under the Toxic Exposures Research Program (TERP) that aims to accelerate the launch and execution of clinical trials related to health problems linked to military-related toxic exposures.
What is the main goal of this award?
The main goal is to speed clinical trials that could materially improve how health problems associated with military-related toxic exposures are prevented, treated, or managed, with an emphasis on producing clinically meaningful evidence for service members, veterans, and other affected populations.
Is this opportunity focused on basic research or clinical trials?
This opportunity is focused on moving interventions into real-world testing through clinical trials, rather than supporting early-stage basic research alone.
What kinds of clinical trials can be proposed?
The program is flexible and allows a range of clinical trial types and scales, from small proof-of-concept efforts to large-scale trials, as long as the work is clinically relevant to health outcomes tied to military-related toxic exposures.
Are pilot studies or early clinical studies allowed?
Yes. Smaller proof-of-concept efforts are explicitly included, such as pilot studies, first-in-human testing, or phase 0 trials that focus on feasibility, protocol refinement, and generating data to support larger trials.
Are large-scale clinical trials allowed?
Yes. Applicants may propose large-scale trials, including pragmatic clinical trials intended to evaluate effectiveness in routine clinical settings and relevant patient populations.
What is a pragmatic clinical trial in the context of this opportunity?
Based on the posting, pragmatic clinical trials are larger-scale studies designed to evaluate effectiveness in real-world, routine clinical settings and in patient populations that are relevant to toxic exposure-related health outcomes.
What health issues must the proposed trial address?
The trial must have clear relevance to conditions or symptoms that arise from, or are worsened by, toxic exposure histories connected to military service.
Who is expected to benefit from the evidence generated by supported trials?
The expectation is that trials will deliver clinically meaningful evidence for service members, veterans, and other affected populations.
Is collaboration required for this award?
Yes. Collaboration is a required feature of this opportunity, not an optional enhancement.
What is the required team structure for the application?
Applications must be built around a partnership where an Initiating Principal Investigator leads the effort and works with at least one, and no more than two, collaborating Principal Investigators.
How many collaborating Principal Investigators are permitted?
The application must include at least one collaborating Principal Investigator and no more than two collaborating Principal Investigators.
Are the collaborating Principal Investigators expected to play an active role?
Yes. The announcement indicates the investigators should be meaningfully engaged in delivering one overarching, unified study, with complementary roles that support rapid implementation and successful trial execution.
Does this award support building partnerships and trial infrastructure?
Yes. The award is designed to help teams quickly stand up partnerships, infrastructure, and coordinated study plans needed to run a credible clinical trial.
What federal agency is managing this grant?
This is a discretionary grant opportunity managed by the Department of the Army through USAMRAA.
What is the funding category for this opportunity?
The opportunity is listed under the Science and Technology/Research and Development category.
What is the CFDA number associated with this award?
The CFDA number provided is 12.420.
What is the funding opportunity number?
The funding opportunity number is HT942525TERPCTPA.
When is the application closing date?
The application closing date is October 16, 2025.
Who is eligible to apply?
Eligibility is listed as unrestricted, which generally indicates a wide range of applicant organizations may apply, subject to standard federal grant rules and the specific requirements in the full announcement.
How many awards are expected to be made?
The posting indicates an expectation of a single award.
What is the maximum award amount (award ceiling)?
The award ceiling is not specified in the provided information. Applicants would typically need to consult the full notice for budget limits and related constraints.
Where can applicants find details on budget limits, period of performance, and allowable costs?
The provided information notes that applicants would typically need to consult the full announcement for budget limits, period of performance, cost allowability, and other constraints that determine the appropriate scope of the proposed clinical trial.
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