Opportunity Information: Apply for HT942525TERPCTPA
The DoD Toxic Exposures Clinical Trial Partnership Award (CTPA) is a Fiscal Year 2025 funding opportunity under the Toxic Exposures Research Program (TERP) intended to speed the launch and execution of clinical trials that could materially improve how health problems linked to military-related toxic exposures are prevented, treated, or managed. The program is focused on moving interventions into real-world testing rather than supporting early-stage basic research alone, with the expectation that supported trials will be positioned to deliver clinically meaningful evidence for service members, veterans, and other affected populations. In practical terms, the award is designed to help research teams quickly stand up the partnerships, infrastructure, and coordinated study plans needed to run a credible clinical trial with clear relevance to conditions or symptoms that arise from, or are worsened by, toxic exposure histories connected to military service.
A central feature of this opportunity is flexibility in the type and scale of clinical trial work that can be proposed. Projects may be smaller, proof-of-concept efforts such as pilot studies, first-in-human testing, or phase 0 trials that mainly establish feasibility, refine protocols, and generate the data needed to justify and design larger trials. At the other end of the spectrum, applicants may propose large-scale trials, including pragmatic clinical trials designed to evaluate effectiveness in routine clinical settings and relevant patient populations. This range signals that the program is open both to exploratory clinical testing that de-risks a promising approach and to more definitive trials aimed at determining efficacy or effectiveness at scale, as long as the study addresses health outcomes associated with military-related toxic exposures.
The award emphasizes collaboration as a requirement rather than an optional strength. Applications must be built around a partnership in which an Initiating Principal Investigator leads the effort while working with at least one, and no more than two, collaborating Principal Investigators. The intent is to ensure that the proposed clinical trial is driven by a genuinely integrated team with complementary expertise, capacity, and access to the needed patient populations or clinical environments. The expectation is that these investigators are not simply listed as co-investigators, but are meaningfully engaged in delivering one overarching, unified study, with roles that support rapid implementation and successful trial execution.
Administratively, this is a discretionary grant opportunity managed by the Department of the Army through USAMRAA, and it falls under the Science and Technology/Research and Development category (CFDA 12.420). Eligibility is listed as unrestricted, which generally means a wide range of applicant organizations may apply, subject to standard federal grant rules and the specific requirements in the full announcement. The funding opportunity number is HT942525TERPCTPA, and the application closing date is October 16, 2025. The posting indicates an expectation of a single award, and while the award ceiling is not specified in the provided source text, applicants would typically need to consult the full notice for budget limits, period of performance, cost allowability, and any other constraints that shape the scope of the proposed trial.Apply for HT942525TERPCTPA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Toxic Exposures Clinical Trial Partnership Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2025-06-05.
- Applicants must submit their applications by 2025-10-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted.
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