Opportunity Information: Apply for PAR 24 218

The NIH HEAL Initiative PAINCare Clinician Training Program (PCTP) Mentored Clinical Scientist Development Award (K08) under PAR-24-218 is a career development grant from the National Institutes of Health designed to help launch a cohort of early-career clinician-scientists into independent research careers focused on pain management. The core goal is to provide protected, mentored research time and NIH support during the critical transition period when a clinician-investigator is building the skills, preliminary data, collaborations, and publication record needed to compete for larger independent NIH research awards. This opportunity sits within the broader NIH HEAL (Helping to End Addiction Long-term) Initiative and specifically aligns with the Clinical Research in Pain Management program, meaning supported projects should directly advance evidence and practice-relevant knowledge in pain care.

A key feature of this particular K08 is that it requires Basic Experimental Studies with Humans (BESH). In practice, that means the research is expected to involve prospective studies in humans that are designed to understand fundamental aspects of biology, behavior, or mechanisms, rather than simply observing clinical outcomes in routine care. Applicants should anticipate that NIH will look for rigorous experimental design, clear scientific rationale for involving human participants, and strong attention to participant protections and ethical considerations that come with experimentally oriented studies in people.

The award mechanism is the Mentored Clinical Scientist Development Award (K08), which is traditionally aimed at clinically trained professionals who are committed to a research-intensive career and who need structured mentorship and research development to become independent investigators. The program emphasizes building an independent research program, so competitive applications typically articulate a coherent long-term research direction in pain management, explain how the mentored phase will build the applicant into a leader in that niche, and describe how the training plan, mentorship team, and institutional environment will support the transition to independence.

Eligibility to apply is broad on the organizational side and spans many types of U.S.-based entities. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments. The announcement also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, certain eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments other than federally recognized ones.

At the same time, there are important restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means limited and well-justified elements of the research may occur outside the U.S. or involve foreign collaborations if they are essential to the project and meet NIH policy requirements.

From an administrative standpoint, the opportunity is categorized as a discretionary grant with an NIH funding instrument type of grant, and it is associated with multiple CFDA numbers (93.213, 93.273, 93.398, 93.846, 93.853, 93.865, 93.866), reflecting NIH’s multi-institute structure and the possible involvement of different NIH components in supporting HEAL-related pain research. The listing shows an original closing date of 2027-07-12, indicating that this funding opportunity will remain open through that date (typically with standard NIH receipt cycles and specific due dates detailed in the full announcement). The public synopsis does not specify an award ceiling or the expected number of awards in the provided fields, so applicants would need to consult the full funding opportunity announcement and NIH institute-specific guidance for budget parameters, project period limits, and the anticipated scale of the cohort.

Overall, this program is best understood as a structured on-ramp for clinician-scientists who want to build a durable research career in pain management under the NIH HEAL umbrella. It supports the combination of mentored research training and scientifically rigorous, experimentally oriented human studies, with the explicit intent of helping awardees develop into independent investigators capable of sustaining a long-term research program that improves pain care evidence and practice.

  • The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.398, 93.846, 93.853, 93.865, 93.866.
  • This funding opportunity was created on 2024-06-28.
  • Applicants must submit their applications by 2027-07-12.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 24 218

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