Opportunity Information: Apply for RFA DK 19 022
The Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) funding opportunity (RFA-DK-19-022) is a National Institutes of Health cooperative agreement (U01; clinical trial optional) designed to build a coordinated, multi-site clinical research network focused on diabetes that appears during an episode of acute pancreatitis or develops afterward. The main scientific emphasis is on type 1 diabetes (T1D), but the program also aims to characterize other diabetes phenotypes that may emerge in this clinical setting. The award supports the creation of up to 10 Clinical Centers (CCs) that will work closely with a separately funded Data Coordinating Center (DCC) to run shared protocols, collect harmonized data and biospecimens, and produce generalizable findings across a diverse patient population.
At the core of the consortium is a prospective, longitudinal observational study following people who experience acute pancreatitis and then develop impaired glucose tolerance or diabetes during the episode or in the months that follow. By tracking participants over time, the consortium is expected to clarify how often diabetes occurs after acute pancreatitis, how it evolves clinically, and how different underlying pancreatitis etiologies relate to diabetes onset and progression. The program is also intended to sort out the "type" of diabetes that develops in these patients, distinguishing T1D and other forms through clinical course, laboratory measures, and mechanistic signals, with the broader goal of improving diagnostic accuracy and anticipating treatment needs earlier.
A major deliverable of the consortium is deeper insight into etiology and pathophysiology, particularly around why a subset of acute pancreatitis patients may develop autoimmune features consistent with T1D. To do that, the Clinical Centers, in partnership with the DCC, will pursue immune profiling and genetic studies and will work to identify biomarkers that predict who is most likely to progress from normal glucose handling to impaired glucose tolerance and then to diabetes, including T1D. The FOA highlights the importance of enrolling a racially, ethnically, and geographically diverse cohort, which is critical both for equity and for ensuring that predictive biomarkers and risk models are valid in real-world populations rather than only in narrowly defined groups.
From a structural standpoint, this is a cooperative agreement, meaning NIH will have substantial involvement beyond standard grant oversight, and the CCs are expected to operate as a true consortium with common governance, shared procedures, and coordinated operations with the DCC. The DCC application is not part of this announcement; it is competed separately under RFA-DK-19-023, and the Clinical Centers funded under this FOA would be expected to integrate seamlessly with the DCC for data management, quality control, statistical support, and cross-site coordination.
The opportunity is offered by the U.S. Department of Health and Human Services through NIH, falls under CFDA 93.847, and supports awards with an upper budget limit listed at $175,000 (award ceiling). NIH anticipated making up to 10 awards for Clinical Centers. Eligible applicants are broad and include many government entities (state, county, city/township, special districts), public and private institutions of higher education, tribal governments and organizations, nonprofits with or without 501(c)(3) status, public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses, with additional eligibility details referenced in the full announcement. Key dates included a creation date of December 2, 2019 and an original closing date of March 13, 2020.Apply for RFA DK 19 022
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Dec 02, 2019.
- Applicants must submit their applications by Mar 13, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $175,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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