Opportunity Information: Apply for RFA TS 22 001
The grant opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" (Funding Opportunity Number RFA TS 22 001; CFDA 93.161) is a discretionary research grant from the U.S. Department of Health and Human Services, administered by the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry (CDC/ATSDR). It funds investigator-initiated studies designed to strengthen what is known about factors that may increase the risk of developing ALS. A central purpose is to directly support the mission of the National ALS Registry, which is the CDCs national system for tracking ALS trends and learning more about who develops ALS and why. The Registrys broader goals include estimating ALS incidence (new cases each year), estimating prevalence (how many people are living with ALS at a given time), characterizing the populations most affected, and identifying contributing factors, including environmental exposures, that may influence ALS risk.
The program is specifically looking for research that identifies and evaluates risk factors that could contribute to ALS, with a clear preference for proposals that focus on five topic areas highlighted in the notice: military service related factors, contact sports participation, traumatic brain injury, neuroinflammation, and infectious agents. These preferred areas reflect ongoing scientific and public health interest in how repeated injuries, immune and inflammatory pathways, and possible pathogen related mechanisms might relate to motor neuron degeneration, as well as long standing questions about unique exposure profiles among service members and certain athletic populations. While proposals are expected to align with the overall aim of clarifying ALS risk factors, this emphasis signals that applications closely tied to those five themes are particularly responsive to the funding announcement.
A key feature of the opportunity is that applicants can compete under one of two funding options, depending on the maturity of their evidence base and the intended type of investigation. Funding Option A is meant for projects where there is already a well substantiated body of evidence suggesting a plausible ALS risk factor, and the next step is a more rigorous evaluation. In practice, that typically implies stronger study designs, improved exposure measurement, better control of confounding, larger or more representative samples, or other methodological upgrades that can move an association from suggestive to more convincing. Funding Option B is intended for earlier stage, exploratory, and developmental work, including novel hypotheses that may have limited or incomplete preliminary data. This pathway is meant to help investigators test new ideas, develop approaches, and generate foundational evidence that could justify larger confirmatory studies later.
The opportunity is open to a wide range of applicant organizations, reflecting the broad public health nature of ALS risk factor research. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state controlled institutions of higher education and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories); and for profit organizations other than small businesses, along with other entities as described in the announcements eligibility clarification. This wide eligibility suggests CDC/ATSDR is aiming to attract multidisciplinary teams spanning academia, public health agencies, clinical and epidemiologic researchers, and organizations with specialized access to relevant populations or exposure data.
From a funding and competition standpoint, the award ceiling is listed as $500,000, and the agency anticipated making around 8 awards under the announcement. The opportunity was posted with a creation date of February 14, 2022, and an original application due date of April 18, 2022, with electronic submissions due by 5:00 pm Eastern Time on the deadline date. Overall, the notice is structured to encourage both rigorous, evidence strengthening studies and carefully designed exploratory work, all aimed at improving the quality and usefulness of knowledge about ALS risk factors in a way that complements and advances the National ALS Registrys public health objectives.Apply for RFA TS 22 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.161.
- This funding opportunity was created on Feb 14, 2022.
- Applicants must submit their applications by Apr 18, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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